Human cytokines activate JAK–STAT signaling pathway in porcine ocular tissue
Identifieur interne : 000538 ( Main/Exploration ); précédent : 000537; suivant : 000539Human cytokines activate JAK–STAT signaling pathway in porcine ocular tissue
Auteurs : Elizaveta Fasler-Kan [Suisse, États-Unis] ; Natasha S. Barteneva [États-Unis] ; Sylvia Ketterer [Suisse] ; Kerstin Wunderlich [Suisse] ; Anca Reschner [Suisse, Belgique] ; Asil Nurzhanova [Kazakhstan] ; Josef Flammer [Suisse] ; Jörg Huwyler [Suisse] ; Peter Meyer [Suisse]Source :
- Xenotransplantation [ 0908-665X ] ; 2013-11.
Abstract
The JAK/STAT (Janus Tyrosine Kinase, Signal Transducers and Activators of Transcription) pathway is associated with cytokine or growth factor receptors and it is critical for growth control, developmental regulation and homeostasis. The use of porcine ocular cells as putative xenotransplants appears theoretically possible. The aim of this study was to investigate the response of various porcine ocular cells in vitro to human cytokines in regard to the activation of JAK‐STAT signaling pathways.
Url:
DOI: 10.1111/xen.12070
Affiliations:
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xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biomedicine, University of Basel and University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Ophthalmology, University of Basel and University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Reschner, Anca" sort="Reschner, Anca" uniqKey="Reschner A" first="Anca" last="Reschner">Anca Reschner</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biomedicine, University of Basel and University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Current Address: Department of Infectious and Parasitic Disease, University of Liege, Liege</wicri:regionArea><wicri:noRegion>Liege</wicri:noRegion></affiliation></author><author><name sortKey="Nurzhanova, Asil" sort="Nurzhanova, Asil" uniqKey="Nurzhanova A" first="Asil" last="Nurzhanova">Asil Nurzhanova</name><affiliation wicri:level="3"><country xml:lang="fr">Kazakhstan</country><wicri:regionArea>Department of Education and Science, Al‐Farabi Kazakh National University, Almaty</wicri:regionArea><placeName><settlement type="city">Almaty</settlement><region nuts="2">Oblys d'Almaty</region></placeName></affiliation></author><author><name sortKey="Flammer, Josef" sort="Flammer, Josef" uniqKey="Flammer J" first="Josef" last="Flammer">Josef Flammer</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Ophthalmology, University of Basel and University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Huwyler, Jorg" sort="Huwyler, Jorg" uniqKey="Huwyler J" first="Jörg" last="Huwyler">Jörg Huwyler</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, Peter" sort="Meyer, Peter" uniqKey="Meyer P" first="Peter" last="Meyer">Peter Meyer</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Biomedicine, University of Basel and University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Ophthalmology, University of Basel and University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Xenotransplantation</title><title level="j" type="abbrev">Xenotransplantation</title><idno type="ISSN">0908-665X</idno><idno type="eISSN">1399-3089</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-11">2013-11</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="469">469</biblScope><biblScope unit="page" to="480">480</biblScope></imprint><idno type="ISSN">0908-665X</idno></series><idno type="istex">78B32951423F4F852832D395F1EA5DDFB4CDDEB4</idno><idno type="DOI">10.1111/xen.12070</idno><idno type="ArticleID">XEN12070</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0908-665X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The JAK/STAT (Janus Tyrosine Kinase, Signal Transducers and Activators of Transcription) pathway is associated with cytokine or growth factor receptors and it is critical for growth control, developmental regulation and homeostasis. The use of porcine ocular cells as putative xenotransplants appears theoretically possible. The aim of this study was to investigate the response of various porcine ocular cells in vitro to human cytokines in regard to the activation of JAK‐STAT signaling pathways.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Kazakhstan</li><li>Suisse</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>Oblys d'Almaty</li></region><settlement><li>Almaty</li><li>Boston</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Fasler An, Elizaveta" sort="Fasler An, Elizaveta" uniqKey="Fasler An E" first="Elizaveta" last="Fasler-Kan">Elizaveta Fasler-Kan</name></noRegion><name sortKey="Fasler An, Elizaveta" sort="Fasler An, Elizaveta" uniqKey="Fasler An E" first="Elizaveta" last="Fasler-Kan">Elizaveta Fasler-Kan</name><name sortKey="Flammer, Josef" sort="Flammer, Josef" uniqKey="Flammer J" first="Josef" last="Flammer">Josef Flammer</name><name sortKey="Huwyler, Jorg" sort="Huwyler, Jorg" uniqKey="Huwyler J" first="Jörg" last="Huwyler">Jörg Huwyler</name><name sortKey="Ketterer, Sylvia" sort="Ketterer, Sylvia" uniqKey="Ketterer S" first="Sylvia" last="Ketterer">Sylvia Ketterer</name><name sortKey="Meyer, Peter" sort="Meyer, Peter" uniqKey="Meyer P" first="Peter" last="Meyer">Peter Meyer</name><name sortKey="Meyer, Peter" sort="Meyer, Peter" uniqKey="Meyer P" first="Peter" last="Meyer">Peter Meyer</name><name sortKey="Reschner, Anca" sort="Reschner, Anca" uniqKey="Reschner A" first="Anca" last="Reschner">Anca Reschner</name><name sortKey="Wunderlich, Kerstin" sort="Wunderlich, Kerstin" uniqKey="Wunderlich K" first="Kerstin" last="Wunderlich">Kerstin Wunderlich</name><name sortKey="Wunderlich, Kerstin" sort="Wunderlich, Kerstin" uniqKey="Wunderlich K" first="Kerstin" last="Wunderlich">Kerstin Wunderlich</name></country><country name="États-Unis"><noRegion><name sortKey="Fasler An, Elizaveta" sort="Fasler An, Elizaveta" uniqKey="Fasler An E" first="Elizaveta" last="Fasler-Kan">Elizaveta Fasler-Kan</name></noRegion><name sortKey="Barteneva, Natasha S" sort="Barteneva, Natasha S" uniqKey="Barteneva N" first="Natasha S." last="Barteneva">Natasha S. Barteneva</name></country><country name="Belgique"><noRegion><name sortKey="Reschner, Anca" sort="Reschner, Anca" uniqKey="Reschner A" first="Anca" last="Reschner">Anca Reschner</name></noRegion></country><country name="Kazakhstan"><region name="Oblys d'Almaty"><name sortKey="Nurzhanova, Asil" sort="Nurzhanova, Asil" uniqKey="Nurzhanova A" first="Asil" last="Nurzhanova">Asil Nurzhanova</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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